12/11/2023 0 Comments Bdnf transport from axon to dendrite![]() TrkB, a neural receptor protein-tyrosine kinase: evidence for a full-length and two truncated receptors. The trkB tyrosine protein kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domain. Expression of the naturally occurring truncated trkB neurotrophin receptor induces outgrowth of filopodia and processes in neuroblastoma cells. Truncated and full-length trkB receptors regulate distinct modes of dendritic growth. Destabilization of cortical dendrites and spines by BDNF. ![]() Horch, H.W., Kruttgen, A., Portbury, S.D. Brain-derived neurotrophic factor differentially regulates retinal ganglion cell dendritic and axonal arborization in vivo. TrkB signaling modulates spine density and morphology independent of dendrite structure in cultured neonatal purkinje cells. ![]() Opposing roles for endogenous BDNF and NT-3 in regulating cortical dendritic growth. Neurotrophins regulate dendritic growth in developing visual cortex. Activity-dependent transfer of brain-derived neurotrophic factor to post-synaptic neurons. Regulated release and polarized localization of brain-derived neurotrophic factor in hippocampal neurons. Requirement for BDNF in activity-dependent survival of cortical neurons. Activity dependent regulation of BDNF and NGF mRNAs in the rat hippocampus is mediated by non-NMDA glutamate receptors. Zafra, F., Hengerer, B., Leibrock, J., Thoenen, H. Afferent innervation influences the development of dendritic branches and spines via both activity-dependent and non-activity-dependent mechanisms. Kossel, A.H., Williams, C.V., Schweizer, M. Promotion of dendritic growth by CPG15, an activity-induced signaling molecule. Regulation of cortical dendrite development by Slit-Robo interactions. Relationships between segregated afferents and postsynaptic neurons in the optic tectum of three-eyed frogs. Local circuitry of identified projection neurons in cat visual cortex brain slices. Relationships between dendritic fields and functional architecture in striate cortex of normal and visually deprived cats. Cells which develop without intercellular contacts. An electron microscopic study of the development of axons and dendrites by hippocampal neurons in culture I. Thus, BDNF released from an individual cell alters the structure of nearby dendrites on an exquisitely local scale.īartlett, W.P. Three-dimensional analysis of donor and recipient dendrites indicated that the BDNF source had to be within 4.5 μm to induce dendritic growth in the recipient neuron. BDNF released from dendrites and cell bodies acted directly on nearby recipient neurons to increase dendritic branching in a distance-dependent manner. Using two-photon microscopy, we analyzed their effects on 'recipient neurons' that expressed green fluorescent protein (GFP) alone. To probe the consequences of such endogenous neurotrophin distribution, we produced 'donor neurons' in ferret cortex brain slices that co-expressed brain-derived neurotrophic factor (BDNF) and red fluorescent protein (RFP). In vivo, however, release of endogenous neurotrophins from neuronal processes creates spatially heterogeneous neurotrophin distributions. In cultured neurons, the exogenous application of neurotrophins (in homogenous concentrations) alters many features of axonal and dendritic arbors.
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